Find coaches from Buffalo (NY) to Florence (SC), US

Find affordable coach tickets from Buffalo (NY) to Florence (SC), US with flexible options. Book your journey now

Join 75M+ travellers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every stage.
Cancel anytime and receive a 100% refund, no reason needed.
Today1 Jun
Tomorrow2 Jun
Tue3 Jun
from US$162
Wed4 Jun
from US$162
Thu5 Jun
Fri6 Jun
Sat7 Jun
Sun8 Jun

Cheap buses leaving Tuesday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: 3 June at
    Departure city: Buffalo
    Departure location: Buffalo (BUF) Airport
    Arrival time: 4 June at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: 3 June at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 4 June at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 3 June at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 4 June at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: 3 June at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 5 June at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: 3 June at
    Departure city: Buffalo
    Departure location: Niagara Frontier Transportation Authority
    Arrival time: 4 June at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to travel from Buffalo to Florence

Bus
Average priceUS$162 - US$296Average duration1d 6h
24kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$237 - US$382Average duration22h 35m
88kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Buffalo to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 22 hours 35 minutes and with fares starting at just US$237, it presents an excellent value for a comfortable ride.

2train per day
22h 35mAverage duration
US$237Cheapest ticket
88kgCO₂ emissions

Bus Buffalo to Florence: Trip Overview

Average ticket priceUS$188
Average bus trip duration1d 6h
Number of daily buses4
Earliest bus departure00:55
Distance601 miles
Latest bus departure23:59

Buffalo to Florence Bus

Busbud helps you find a bus from Buffalo to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Buffalo to Florence will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Buffalo to Florence, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Buffalo (NY) - Florence (SC), US

  1. How much is coach from Buffalo to Florence?

    The price for a coach ticket from Buffalo to Florence starts at US$162, though the average is US$188. The actual price may differ based on factors like the time you plan to travel, the day of the week, and the coach service provider you select. To get accurate and up-to-date pricing information, check out all your options on our search tool.

  2. How long does the coach from Buffalo to Florence take?

    The average duration for a trip from Buffalo to Florence by coach is around 1d 6h. The fastest coach journey typically takes 1d 4h. However, please keep in mind that your specific travel time may vary due to the prevailing traffic conditions along the route.

  3. At what time does the first coach from Buffalo to Florence leave?

    The first departure to Florence is at 00:55. Keep in mind that departure times might change on weekends and holidays.

  4. What's the distance between Buffalo and Florence by coach?

    The distance between Buffalo and Florence by coach is approximately 601 miles (969 km).

  5. How can I travel from Buffalo to Florence avoiding air travel?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

  6. Can I catch a night coach from Buffalo to Florence?

    Yes, you can find coaches leaving until 23:59 and arriving the next day. Remember to bring along some essentials like a snuggly blanket and a few treats for a comfortable trip.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
30/05
No data
31/05
US$164
Today
No data
02/06
No data
03/06
US$178
04/06
US$193
05/06
No data
06/06
No data
busbud logoThe cheapest trip from Buffalo to Florence was searched and found on 31 May 2025 with a price of US$164

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo to Florence as early as possible.

You can expect to pay from US$164 to US$195 for a bus ticket from Buffalo to Florence based on the last 2 days. You can expect to find the cheapest price for the trip at US$178, which is on 2025-06-03.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Buffalo and Florence!

Much more than a mere vehicle taking you from Buffalo to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Buffalo to Florence that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Buffalo to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Buffalo to Florence?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Buffalo by bus?

Bus from Buffalo to Florence

You can also go to Florence by train

Train from Buffalo to Florence

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Buffalo

Buses Leaving from Buffalo

Buses Going to Buffalo

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence