Bus Tickets from Chicago to Tupelo

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TodayJun 2
from $149
TomorrowJun 3
WedJun 4
ThuJun 5
from $123
FriJun 6
SatJun 7
from $102
SunJun 8
from $113
MonJun 9

Cheap buses leaving Thursday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 5 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: June 6 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 5 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: June 6 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 5 at
    Departure city: Chicago
    Departure location: Downtown Greyhound Station
    Arrival time: June 6 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 5 at
    Departure city: Chicago
    Departure location: Chicago 95Th & Dan Ryan
    Arrival time: June 6 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 5 at
    Departure city: Chicago
    Departure location: 537-517 W. Jackson Blvd
    Arrival time: June 6 at
    Destination city: Tupelo
    Destination location: Tupelo (Brothers Quick Stop)
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Chicago to Tupelo: Trip Overview

Average ticket price$152
Average bus trip duration22h 55m
Number of daily buses4
Earliest bus departure6:10am
Distance530 miles (854 km)
Latest bus departure10:30pm

Chicago to Tupelo Bus

With Busbud, comparing and booking tickets for a bus from Chicago to Tupelo is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from Chicago to Tupelo.

Discover how much the bus trip from Chicago to Tupelo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Chicago - Tupelo

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/31
No data
06/01
No data
Today
$141
06/03
No data
06/04
No data
06/05
$115
06/06
No data
06/07
$95
busbud logoThe cheapest trip from Chicago to Tupelo was searched and found on Jun 7, 2025 with a price of $95

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.

You can expect to pay from $95 to $206 for a bus ticket from Chicago to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $95 which is on 2025-06-07.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Chicago to Tupelo.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Chicago to Tupelo.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Tupelo will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Chicago to Tupelo while indulging in miles on end of beautiful scenic views.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Chicago by bus?

Bus from Chicago to Tupelo

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