Bus Chicago to Winston-Salem: Trip Overview
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Chicago to Winston-Salem Bus
Busbud helps you find a bus from Chicago to Winston-Salem. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Chicago to Winston-Salem from the most reliable bus companies operating this trip.
Discover how much the bus trip from Chicago to Winston-Salem will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Chicago and Winston-Salem?
Frequently asked questions for your trip Chicago - Winston-Salem
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Winston-Salem was searched and found on Jun 6, 2025 with a price of $129To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Winston-Salem, as early as possible.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Winston-Salem!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Chicago to Winston-Salem, get comfy and count the stars.
Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Chicago to Winston-Salem will emit less CO2 than a car or an airplane.
Make a music playlist for your bus ride from Chicago to Winston-Salem, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.
One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.
Top traveled bus routes
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Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.