Bus Tickets from Knoxville, TN to Chicago

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TodayJun 28
from $113
TomorrowJun 29
from $158
MonJun 30
from $141
TueJul 1
from $145
WedJul 2
from $144
ThuJul 3
from $159
FriJul 4
from $107
SatJul 5
from $143

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 29 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 30 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 29 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 30 at
    Destination city: Chicago
    Destination location: 537-517 W. Jackson Blvd
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 29 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 30 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 29 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 30 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 29 at
    Departure city: Knoxville
    Departure location: Knoxville Bus Station
    Arrival time: June 30 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Bus Knoxville to Chicago: Trip Overview

Average ticket price$140
Average bus trip duration16h 35m
Number of daily buses5
Earliest bus departure6:15pm
Distance443 miles (714 km)
Latest bus departure10:15pm

Knoxville to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Knoxville to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Knoxville to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Knoxville to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Knoxville, TN - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/26
$138
06/27
$154
Today
$106
06/29
$152
06/30
$133
07/01
$160
07/02
$182
07/03
$172
busbud logoThe cheapest trip from Knoxville to Chicago was searched and found on Jun 28, 2025 with a price of $106

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville to Chicago, as early as possible.

You can expect to pay from $106 to $205 for a bus ticket from Knoxville to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $133 which is on 2025-06-30.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Knoxville to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Knoxville to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Knoxville to Chicago will emit less CO2 than a car or an airplane.

Tune out to the fine sounds of your best music playlist on your bus trip from Knoxville to Chicago while indulging in miles on end of beautiful scenic views.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Knoxville by bus?

Bus from Knoxville to Chicago

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