Bus Tickets from La Serena to Santiago

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TodayMay 14
from $9
TomorrowMay 15
from $8
FriMay 16
from $9
SatMay 17
from $9
SunMay 18
from $9
MonMay 19
from $9
TueMay 20
from $8
WedMay 21
from $8

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 15 at
    Departure city: La Serena
    Departure location: La Serena (Bus terminal La Serena)
    Arrival time: May 15 at
    Destination city: Santiago
    Destination location: Terminal San Borja
    Operated by: Flixbus ChileFlixbus Chile
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 15 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 15 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: May 15 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 15 at
    Destination city: Santiago
    Destination location: Terminal de Buses San Borja - San Francisco de Borja
    Operated by: Cikbus ElitéCikbus Elité
    Vehicle: BusDuration:
  • Departure time: May 15 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 15 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: Pluss ChilePluss Chile
    Vehicle: BusDuration:
  • Departure time: May 15 at
    Departure city: La Serena
    Departure location: Terminal de Buses La Serena
    Arrival time: May 16 at
    Destination city: Santiago
    Destination location: San Borja
    Operated by: ParaviasParavias
    Vehicle: BusDuration:

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Bus La Serena to Santiago: Trip Overview

Average ticket price$16
Average bus trip duration6h 15m
Number of daily buses67
Earliest bus departure12:05am
Distance241 miles (388 km)
Latest bus departure11:59pm

La Serena to Santiago Bus

With Busbud, comparing and booking tickets for a bus from La Serena to Santiago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from La Serena to Santiago will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses traveling from La Serena to Santiago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip La Serena - Santiago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/12
$15
05/13
$13
Today
$9
05/15
$8
05/16
$9
05/17
$9
05/18
$9
05/19
$9
busbud logoThe cheapest trip from La Serena to Santiago was searched and found on May 15, 2025 with a price of $8

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena to Santiago, as early as possible.

You can expect to pay from $8 to $28 for a bus ticket from La Serena to Santiago based on the last 2 days. You can expect to find the cheapest price for the trip at $8 which is on 2025-05-15.

Usually PlussChile, Cikbus Elité, Buses Romani will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from La Serena to Santiago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from La Serena to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from La Serena to Santiago that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from La Serena to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Will you be returning to La Serena by bus?

Bus from La Serena to Santiago

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