Bus Tickets from San Diego, CA to Chicago, IL

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TodayMay 21
from $333
TomorrowMay 22
from $288
FriMay 23
SatMay 24
SunMay 25
MonMay 26
TueMay 27
WedMay 28

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: May 22 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: May 25 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: May 22 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: May 24 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: May 22 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: May 24 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 22 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: May 25 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: May 22 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: May 25 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from San Diego to Chicago.

Bus
Average Price$129 - $551Average Duration2d 10h
70kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$175 - $2,079Average Duration2d 19h
254kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from San Diego to Chicago

Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 2 days, 10 hours 45 minutes and with fares starting at just $129, it presents an excellent value for a comfortable ride.

13bus per day
2d 10hAverage Duration
$129Cheapest ticket
70kgCO₂ emissions

Bus San Diego to Chicago: Trip Overview

Average ticket price$239
Average bus trip duration2d 10h
Number of daily buses13
Earliest bus departure7:15am
Distance1728 miles (2787 km)
Latest bus departure7:35pm

San Diego to Chicago Bus

With Busbud, comparing and booking tickets for a bus from San Diego to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make it our job to connect you with the most dependable bus companies that cover bus service from San Diego to Chicago.

From cheap bus tickets to more luxurious buses traveling from San Diego to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05/19
$242
05/20
$426
Today
$549
05/22
$315
05/23
$186
05/24
$209
05/25
$156
05/26
$172
busbud logoThe cheapest trip from San Diego to Chicago was searched and found on May 25, 2025 with a price of $156

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Chicago, as early as possible.

You can expect to pay from $156 to $584 for a bus ticket from San Diego to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $156 which is on 2025-05-25.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from San Diego to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from San Diego to Chicago.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Chicago that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Chicago.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from San Diego to Chicago?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego by bus?

Bus from San Diego to Chicago

You can also go to Chicago by train

Train from San Diego to Chicago

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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