Bus Tickets from Siena to Palermo

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TodayMay 30
from US$124
TomorrowMay 31
SunJun 1
MonJun 2
TueJun 3
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FriJun 6

Cheap buses leaving today

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: May 30 at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: May 31 at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: May 30 at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: May 31 at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • Departure time: May 30 at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: May 31 at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • Departure time: May 30 at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: May 31 at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:
  • Departure time: May 30 at
    Departure city: Siena
    Departure location: Siena Train Station
    Arrival time: May 31 at
    Destination city: Palermo
    Destination location: Terminal Bus Palermo
    Operated by: Flixbus Flixbus
    Vehicle: BusDuration:

Last refresh of the prices: Yesterday at 4:13 PM CEST.

Prices and availability are subject to change.

Accepted payments

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Compare 2 ways to go from Siena to Palermo

Bus
Average PriceUS$36 - US$124Average Duration19h 30m
15kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Carpool
Average PriceUS$70 - US$70Average Duration13h 30m
25kg CO₂e4 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Siena to Palermo

Among the sustainable travel choices, the bus stands out as a good way to reach Palermo. The journey takes about 19 hours 30 minutes, and with fares starting at just US$36, it presents an excellent value for a comfortable ride.

4bus per day
19h 30mAverage Duration
US$36Cheapest ticket
15kgCO₂ emissions

Bus Siena to Palermo: Trip Overview

Average Ticket PriceUS$57
Average Bus Trip Duration19h 30m
Number of daily buses4
Earliest bus departure2:51pm
Distance604 km
Latest bus departure9:20pm

Siena to Palermo Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Siena to Palermo.

We make sure you can find a bus service from Siena to Palermo from the most reliable bus companies operating this trip.

Discover how much the bus trip from Siena to Palermo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Siena - Palermo

  1. How long is the bus trip from Siena to Palermo?

    The typical travel time from Siena to Palermo by bus is around 19h 30m. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 16h 5m.

  2. How far is Siena from Palermo?

    The distance covered from Siena to Palermo is 604 km (375 miles).

  3. What are the departure and arrival locations for buses traveling from Siena to Palermo?

    Buses traveling this route start their trip at Piazza Gramsci, in Siena, and end it at Terminal Bus Palermo, in Palermo.

  4. What is the cheapest way to go from Siena to Palermo?

    The least expensive way to go from Siena to Palermo would be going by bus. With a starting ticket price of US$36, this bus becomes your top pick for this journey.

  5. How much does it cost to take the bus from Siena to Palermo?

    The bus fare from Siena to Palermo is approximately US$57.

  6. Can I take an overnight bus from Siena to Palermo?

    Yes! Catch buses leaving from Siena until 9:20pm and reaching Palermo on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
05-28
No data
05-29
No data
Today
US$116
05-31
No data
06-01
No data
06-02
No data
06-03
No data
06-04
No data
busbud logoThe cheapest trip from Siena to Palermo was searched and found on May 30, 2025 with a price of US$116

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Siena to Palermo, as early as possible.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Siena to Palermo but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Siena to Palermo, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Siena to Palermo will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Siena to Palermo.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

What's the cheapest way to go from Siena to Palermo?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Siena by bus?

Bus from Siena to Palermo

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