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One passenger / one way
- This trip is recommended because it is: Cheapest + FastestDeparture time: June 28 atDeparture city: MobileDeparture location: Greyhound StationArrival time: June 28 atDestination city: KnoxvilleDestination location: Knoxville Bus StationOperated by: Greyhound Lines, Inc.
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Bus Mobile to Knoxville: Trip Overview
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Mobile to Knoxville Bus
Busbud helps you find a bus from Mobile to Knoxville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
We make sure you can find a bus service from Mobile to Knoxville from the most reliable bus companies operating this trip.
Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Mobile, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Mobile and Knoxville?
Frequently asked questions for your trip Mobile - Knoxville, TN
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mobile to Knoxville was searched and found on Jun 25, 2025 with a price of $117To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mobile to Knoxville, as early as possible.
You can expect to pay from $117 to $145 for a bus ticket from Mobile to Knoxville based on the last 2 days. You can expect to find the cheapest price for the trip at $122 which is on 2025-07-02.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Mobile and Knoxville!
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Mobile to Knoxville, get comfy and count the stars.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Mobile to Knoxville.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Mobile to Knoxville.
Did you know?
It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.
The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.
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Popular Buses Connecting Mobile
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
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Buses Going to Knoxville
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