Bus Tickets from Indianapolis to San Diego (CA), US

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TodayJun 3
from US$269
TomorrowJun 4
from US$397
ThuJun 5
from US$402
FriJun 6
SatJun 7
SunJun 8
MonJun 9
TueJun 10

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: June 4 at
    Departure city: Indianapolis
    Departure location: Downtown Transit Center
    Arrival time: June 7 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: June 4 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: June 6 at
    Destination city: San Diego
    Destination location: UCSD Health La Jolla Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 4 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: June 6 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 4 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: June 6 at
    Destination city: San Diego
    Destination location: Greyhound Bus Stop
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 4 at
    Departure city: Indianapolis
    Departure location: Indianapolis Bus Station
    Arrival time: June 6 at
    Destination city: San Diego
    Destination location: San Diego (Old Town-FlixBus)
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

Last refresh of the prices: Last Saturday at 8:20 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
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  • American Express
  • China Union Pay
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Compare 2 ways to go from Indianapolis to San Diego

Average PriceUS$117 - US$502Average Duration2d 13h
72kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Average PriceUS$207 - US$346Average Duration2d 9h
262kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Indianapolis to San Diego

Among the sustainable travel choices, the train stands out as a good way to reach San Diego. The journey takes about 2 days, 9 hours 53 minutes, and with fares starting at just US$207, it presents an excellent value for a comfortable ride.

2train per day
2d 9hAverage Duration
US$207Cheapest ticket
262kgCO₂ emissions

Bus Indianapolis to San Diego: Trip Overview

Average Ticket PriceUS$226
Average Bus Trip Duration2d 13h
Number of daily buses23
Earliest bus departure3:15am
Distance2874 km
Latest bus departure11:30pm

Indianapolis to San Diego Bus

With Busbud, comparing and booking tickets for a bus from Indianapolis to San Diego is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Indianapolis to San Diego from the most reliable bus companies operating this trip.

Discover how much the bus trip from Indianapolis to San Diego will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Indianapolis - San Diego (CA), US

  1. How long does it take to get to San Diego from Indianapolis by bus?

    The trip from Indianapolis to San Diego will take on average 2d 13h. If you're looking for the fastest way to get there, you'll find a bus doing the trip in about 2d.

  2. What is the distance between Indianapolis and San Diego?

    It's about 2876 km (1783 miles) from Indianapolis to San Diego.

  3. What are the departure and arrival locations for buses traveling from Indianapolis to San Diego?

    Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Mission Valley Sheraton, in San Diego.

  4. What is the cheapest way to travel from Indianapolis to San Diego?

    If you're on a budget, consider traveling by bus to San Diego from Indianapolis; it tends to be more affordable. With a starting ticket price of US$117, this bus becomes your top pick for this journey.

  5. How much is the bus from Indianapolis to San Diego?

    Taking the bus from Indianapolis to San Diego costs on average US$226.

  6. Is it possible to travel by overnight bus from Indianapolis to San Diego?

    Yes! Catch buses leaving from Indianapolis until 11:30pm and reaching San Diego on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-01
US$394
06-02
US$536
Today
US$262
06-04
US$445
06-05
US$409
06-06
No data
06-07
No data
06-08
No data
busbud logoThe cheapest trip from Indianapolis to San Diego was searched and found on Jun 3, 2025 with a price of US$262

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to San Diego, as early as possible.

You can expect to pay from US$262 to US$603 for a bus ticket from Indianapolis to San Diego based on the last 2 days. You can expect to find the cheapest price for the trip at US$409 which is on 2025-06-05.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from Indianapolis to San Diego.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Indianapolis to San Diego, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Indianapolis to San Diego will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Indianapolis to San Diego, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

Will you be returning to Indianapolis by bus?

Bus from Indianapolis to San Diego

You can also go to San Diego by train

Train from Indianapolis to San Diego

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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Popular Buses Connecting Indianapolis

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