Bus Tickets from Jacksonville (FL) to Key West

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TodayJun 4
TomorrowJun 5
from US$149
FriJun 6
SatJun 7
SunJun 8
MonJun 9
TueJun 10
WedJun 11

Cheap buses leaving tomorrow

One passenger / one way

  • This trip is recommended because it is the: Cheapest + Fastest
    Departure time: June 5 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: June 6 at
    Destination city: Key West
    Destination location: Key West Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 5 at
    Departure city: Jacksonville
    Departure location: Jacksonville Bus Station
    Arrival time: June 6 at
    Destination city: Key West
    Destination location: Key West Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Today at 12:56 PM EDT.

Prices and availability are subject to change.

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Bus Jacksonville to Key West: Trip Overview

Average Ticket PriceUS$52
Average Bus Trip Duration17h 25m
Number of daily buses2
Earliest bus departure4:05pm
Distance642 km
Latest bus departure9:45pm

Jacksonville to Key West Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Jacksonville to Key West.

Bus service from Jacksonville to Key West will be provided by the most trusted bus companies.

Discover how much the bus trip from Jacksonville to Key West will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions on the trip Jacksonville (FL) - Key West

  1. How long is the trip from Jacksonville to Key West by bus?

    The typical travel time from Jacksonville to Key West by bus is around 17h 25m. For the shortest travel time, select the fastest bus available, which will take you to Key West in about 17h 25m.

  2. What is the travel distance from Jacksonville to Key West?

    The distance covered from Jacksonville to Key West is 643 km (399 miles).

  3. What are the departure and arrival locations for buses traveling from Jacksonville to Key West?

    Buses traveling this route start their trip at Jacksonville Amtrak Station, in Jacksonville, and end it at Caroline St, in Key West.

  4. What is the cheapest way to go from Jacksonville to Key West?

    The least expensive option to go from Jacksonville to Key West would be going by bus. The ticket price for this bus starts at US$51, making this your best choice for this trip.

  5. How much does the bus ticket cost from Jacksonville to Key West?

    The bus fare from Jacksonville to Key West is approximately US$52.

  6. Is there an overnight bus from Jacksonville to Key West?

    Yes! Catch buses leaving from Jacksonville until 9:45pm and reaching Key West on the following day.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06-02
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06-03
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Today
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06-05
US$141
06-06
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06-07
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06-08
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06-09
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busbud logoThe cheapest trip from Jacksonville to Key West was searched and found on Jun 5, 2025 with a price of US$141

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville to Key West, as early as possible.

You can expect to pay from US$141 to US$141 for a bus ticket from Jacksonville to Key West based on the last 2 days. You can expect to find the cheapest price for the trip at US$141 which is on 2025-06-05.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Jacksonville to Key West but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Jacksonville to Key West, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Jacksonville to Key West will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from Jacksonville to Key West, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Jacksonville by bus?

Bus from Jacksonville to Key West

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